The reduction in NO may result in different pathophysiological events like vasoconstriction, high adhesion, and endothelial activation [206]
In some cases, due to similar amphiphilicity between cell membrane and liposome, the functional proteins from the membranes could be inserted inside the liposomal bilayer after protein fusion, generating proteolipid nanoparticles
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This upregulation leads to the direct suppression of proline hydroxylase 1 and 2 by miR-23a, resulting in the accumulation of HIF1 in endothelial cells [90]
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